Tesamorelin is a synthetic analogue of human growth hormone-releasing hormone (GHRH 1-44) carrying a trans-3-hexenoyl group on the N-terminal tyrosine. This modification substantially slows enzymatic degradation relative to native GHRH while preserving receptor affinity. It stimulates the pituitary to release growth hormone in a pulsatile, physiologically patterned manner, and is studied extensively in visceral adipose tissue and IGF-1 axis research.
| Scientific name | Trans-3-hexenoyl-GHRH(1-44) Amide |
|---|---|
| CAS number | 218949-48-5 |
| Molecular formula | C221H366N72O67S |
| Molecular weight | 5135.9 g/mol |
| Sequence | Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2 |
| Form | Lyophilized Powder |
| HPLC purity | 99.5% |
Store lyophilized powder at -20°C for up to 24 months, protected from light and moisture. After reconstitution, refrigerate at 2°C to 8°C and use within 14 days.
Add 2.0 mL of Sterile Bacteriostatic Water down the inside wall of the vial. Let it stand for 2-3 minutes, then swirl gently until dissolved. Do not shake — vigorous agitation can denature the peptide chain.
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For laboratory research use only. Products are not approved by the FDA or EMA for human or veterinary use, and are not drugs, dietary supplements or cosmetics.