Semaglutide 10mg — Long-Acting GLP-1 Receptor Agonist Research Peptide

Semaglutide is a 31-amino-acid analogue of human GLP-1 with roughly 94% sequence homology to the native hormone. Two substitutions (Aib at position 8 and Arg at position 34) confer resistance to DPP-4 degradation, while a C18 diacid chain attached at Lys26 through a hydrophilic linker drives strong albumin binding. Together these modifications extend the circulating half-life to approximately one week, making it a central reference compound in incretin and energy-balance research.

Specifications

Scientific name	Semaglutide Acetate
CAS number	910463-68-2
Molecular formula	C187H291N45O59
Molecular weight	4113.58 g/mol
Sequence	His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly
Form	Lyophilized Powder
HPLC purity	99.5%

Research applications

• Selective GLP-1 receptor agonism for incretin-pathway research.
• DPP-4 resistant backbone enables extended in vitro and in vivo study windows.
• Widely used in preclinical models of glycaemic control and satiety signalling.
• Albumin-binding side chain supports long-acting pharmacokinetic study designs.

Storage

Store lyophilized powder at -20°C for up to 2 years. Keep desiccated and shielded from light. After reconstitution, store at 2°C to 8°C (refrigerated) and use within 14 days. Avoid freeze-thaw cycles.

Reconstitution

Introduce 2.0 mL of Sterile Bacteriostatic Water slowly along the vial wall. Allow to stand for 2-3 minutes, then swirl gently until fully dissolved. The resulting solution should be clear and free of particulates.

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For laboratory research use only. Products are not approved by the FDA or EMA for human or veterinary use, and are not drugs, dietary supplements or cosmetics.